A malign mesenchymal tumor (sarcoma) of the pulmonary artery presenting as a for..
Wednesday, February 3, 2010
(Source: The Clinical Respiratory Journal) .. read more..
World Cancer Day 2010
Tuesday, February 2, 2010
February 4th marks World Cancer Day, a day that bring global awareness to the disease. This year\'s theme is \"Cancer Can Be Prevented Too\" and focuses on the avoiding the common causes of cancer. This is an increased concentration this year of raising awareness about infections that cause cancer. One.. .. read more..
Review: Ewing\'s sarcoma
Tuesday, February 2, 2010
Source: Lancet Oncology Area: News The Lancet Oncology has featured a review on Ewing\'s sarcoma, a common bone tumour in children and adolescents. The review covers the following: - Epidemiology - Diagnosis, imaging, and staging - Molecular diagnosis and staging - Imaging .. .. read more..
Clear cell sarcoma of the kidney in children: experience in a developing country
Tuesday, February 2, 2010
Conclusion In a developing country, CCSK is rare and clinically and radiologically indistinguishable from Wilms tumour. Associated hypertension is common. Pretreatment diagnosis is difficult and sampling errors using needle biopsies may be unavoidable. Treatment results are poor and, give.. .. read more..
(−)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by..
Monday, February 1, 2010
Conclusions Our findings demonstrate that EGCG is effective for growth inhibition of a chondrosarcoma cell lines in vitro, and suggest that EGCG may be a new therapeutic option for patients with chondrosarcoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0765.. .. read more..
[Articles] Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R..
Sunday, January 31, 2010
Figitumumab is a fully human IgG2 monoclonal antibody targeting the insulin-like growth-factor-1 receptor (IGF-1R). Preclinical data suggest a dependence on insulin-like growth-factor signalling for sarcoma subtypes, including Ewing\'s sarcoma, and early reports show antitumour activity of IGF-1R-tar.. .. read more..
Partial Hand Preservation for Large Soft Tissue Sarcomas of the Hand
Sunday, January 31, 2010
Conclusions: Partial hand preservation is possible in selected patients with large soft tissue sarcomas of the hand, obtaining low local recurrence rates, good overall survival, and good functional outcome. However, all effort should be made to achieve negative resection margins.Type of study/level .. .. read more..
Undifferentiated sarcoma of the thyroid in a child
Sunday, January 31, 2010
The most common malignant tumor of the thyroid is papillary carcinoma. Sarcoma of the thyroid is encountered very rarely; its therapy is complex and poses significant problems due to the problematic location of the tumor. A 14-year-old female was diagnosed with undifferentiated sarcoma of the thyroi.. .. read more..
[Review] Ewing\'s sarcoma
Sunday, January 31, 2010
Progress in the treatment of Ewing\'s sarcoma, the second most common bone tumour in children and adolescents, has improved survival from about 10% in the period before chemotherapy was introduced to about 75% today for patients with localised tumours. However, patients with metastases still fare bad.. .. read more..
[Reflection and Reaction] IGF-1R targeted treatment of sarcoma
Sunday, January 31, 2010
The first study to report in-vitro responses of a Ewing\'s sarcoma cell line to type 1 insulin-like growth factor (IGF-1) was published 20 years ago, and was quickly followed by additional cell-line studies that showed modulation of chemosensitivity by IGF-1. At this time, the IGF-1-initiated signall.. .. read more..
A case of histiocytic sarcoma presenting with primary bone marrow involvement.
Sunday, January 31, 2010
We describe here a 63-yr-old male who manifested systemic symptoms, including fever, weight loss and generalized weakness. Abdominal and chest computed tomography failed to show specific findings, but there was suspicion of multiple bony changes at the lumbar spine. Fusion whole body positron emissi.. .. read more..
Scientists At Massachusetts General Hospital Target Osteosarcoma Gene Therapy
Saturday, January 30, 2010
Scientists discuss in \'Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines\' new findings in osteosarcoma. According to a study from the United States, Insulin-like gro.. .. read more..
Child cancer survivors have higher heart risk: Study
Saturday, January 30, 2010
The cancer survivors had been diagnosed below the age of 21 with either leukemia, brain cancer, Hodgkin\'s lymphoma, non-Hodgkin\'s lymphoma, kidney cancer, neuroblastoma, soft tissue sarcoma, or bone cancer between 1970 and 1986.01/31/2010 (Source: Kidney Cancer Association) .. read more..
Clonal relationship between precursor B-cell acute lymphoblastic leukemia and hi..
Saturday, January 30, 2010
There have been several reports of patients with two hematopoietic neoplasms, one showing B-cell differentiation and the other being a histiocytic (H) or dendritic cell (DC) sarcoma (). It is intriguing that the two neoplasms have been found to be clonally related in all cases with clonality studies.. .. read more..
Radiotherapy and extent of surgical resection in retroperitoneal soft-tissue sar..
Friday, January 29, 2010
To examine the impact of adjuvant radiotherapy (RT) and surgical technique on survival in retroperitoneal soft-tissue sarcoma.A retrospective analysis was conducted using the National Oncology Database, a proprietary database of aggregated tumor registries owned by IMPAC® Medical Systems (Sunnyvale,.. .. read more..
Decreased copy number of mitochondrial DNA in Ewing\'s sarcoma.
Friday, January 29, 2010
CONCLUSIONS: The mtDNA content reduction may be an important genetic event in the carcinogenesis of EWS. This study provides evidence that somatic D-loop mutation is likely one of the key factors contributing to quantitative changes of mtDNA in EWS. PMID: 20123091 [PubMed - as supplied by publisher].. .. read more..
Carney triad versus Carney Stratakis syndrome: two cases which illustrate the di..
Friday, January 29, 2010
This report demonstrates the difficulty in distinguishing between Carney triad and Carney Stratakis syndrome due to the rarity of the individual components. The fact that most patients with Carney triad have only two components of the Triad, and the long interval often seen between the occurrence of.. .. read more..
[News of the Week] Global Health: Haiti\'s Quake Shifts Clinic\'s Focus From AIDS ..
Friday, January 29, 2010
Since the 12 January earthquake, GHESKIO (the Haitian Group for the Study of Kaposi\'s Sarcoma and Opportunistic Infections) has converted itself into a hospital with a surgical unit and a makeshift outdoor home for thousands of refugees. On 21 January, GHESKIO leader Jean \"Bill\" Pape responded to qu.. .. read more..
Postoperative nomogram for survival of patients with retroperitoneal sarcoma tre..
Thursday, January 28, 2010
Conclusions: A RPS-specific postoperative nomogram was developed. It improves RPS staging by allowing a more dynamic and robust disease-specific risk stratification. This prognostic tool can help in patient counseling and for selection of high-risk patients that may benefit from adjuvant therapies o.. .. read more..
Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplific..
Thursday, January 28, 2010
Authors: Michael J Cascio, Richard J O\'Donnell & Andrew E Horvai (Source: Modern Pathology AOP) .. read more..